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Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Mishra S, Welch N, Karthikeyan M, Bellar A, Musich R, Singh SS, Zhang D, Sekar J, Attaway AH, Chelluboyina AK, Lorkowski SW, Roychowdhury S, Li L, Willard B, Smith JD, Hoppel CL, Vachharajani V, Kumar A, Dasarathy S. Mishra S, et al. Aging Cell. 2023 Jul;22(7):e13852. doi: 10.1111/acel.13852. Epub 2023 Apr 26. Aging Cell. 2023. PMID: 37101412 Free PMC article.
Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.
Blum AE, Venkitachalam S, Ravillah D, Chelluboyina AK, Kieber-Emmons AM, Ravi L, Kresak A, Chandar AK, Markowitz SD, Canto MI, Wang JS, Shaheen NJ, Guo Y, Shyr Y, Willis JE, Chak A, Varadan V, Guda K. Blum AE, et al. Among authors: chelluboyina ak. Gastroenterology. 2019 May;156(6):1761-1774. doi: 10.1053/j.gastro.2019.01.263. Epub 2019 Feb 12. Gastroenterology. 2019. PMID: 30768984 Free PMC article.